Jul 23, 2024
Contributor: Travis Barlock MD
Educational Pearls:
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Recent study assessed outcomes after ROSC with epinephrine vs. norepinephrine
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Observational multicenter study from 2011-2018
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285 patients received epineprhine and 481 received norepinephrine
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Epinephrine was associated with an increase in all-cause mortality (primary outcome)
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Odds ratio 2.6; 95%CI 1.4-4.7; P = 0.002
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Higher cardiovascular mortality (secondary outcome)
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Higher proportion of unfavorable neurological outcome (secondary outcome)
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Norepinephrine is the vasopressor of choice in post-cardiac arrest care
References
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Bougouin W, Slimani K, Renaudier M, et al. Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock. Intensive Care Med. 2022;48(3):300-310. doi:10.1007/s00134-021-06608-7
Summarized by Jorge Chalit, OMSIII | Edited by Meg Joyce & Jorge Chalit