Recent study compared Compazine with Benadryl vs. Dilaudid for
acute migraine management in the ED.
Compazine + Benadryl demonstrated migraine relief in 60% of
patients compared to the 31% of patients who were relieved with
Dilaudid.
Compazine + Benadryl is a superior migraine treatment than
Dilaudid.
References:
Friedman BW, et. al. (2017). Randomized study of IV
prochlorperazine plus diphenhydramine vs IV hydromorphone for
migraine. Neurology. 89(20):2075-2082
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