Mar 31, 2020
In the past two weeks, warnings,
questions, and misinformation concerning COVID-19 and NSAID use
have been spreading...no pun intended..virally. The pace of this
evolving pandemic and the equally quick pace of the news and social
media news cycle have meant that information and misinformation
travel equally fast. Today we bring to you the story of how a
letter in The Lancet led to a world of
confusion.
Host: Elizabeth
Esty, MD
Research By:
Elizabeth Esty & Nathan Novotny
Sound Editing
By: Stephen Bahmani
Time
Stamps:
0:00 - COVID-19
Statistics
2:55 - The Lancet
Letter: What Started the Rumor
4:10 - ACE Inhibitors &
ARB's
5:00 - What The Lancet
Letter Got Wrong
6:25 - Treatment of HTN and DM
in China vs. the U.S.
9:13 - Do ACE Inhibitors
Actually Increase ACE-2 Expression?
11:00 - The French Ministry of
Health and Their Warning About NSAIDs
14:09 - Misinformation in the
Age of COVID-19
15:09 - Potential Harms of
Tylenol Use
16:11 - The Need for
High-Quality Science to Overcome COVID-19
References:
- Fang L, Karakiulakis G, Roth M. Are patients with hypertension
and diabetes mellitus at increased risk for COVID-19 infection?
The Lancet Respiratory Medicine. March
2020:S2213260020301168. doi:10.1016/S2213-2600(20)30116-8
- Kane S. Ibuprofen - Drug Usage Statistics, ClinCalc DrugStats
Database. ClinCalc DrugStats Database.
https://clincalc.com/DrugStats/Drugs/Ibuprofen. Published December
23, 2019. Accessed March 30, 2020.
- Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell
Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically
Proven Protease Inhibitor. Cell. March 2020.
doi:10.1016/j.cell.2020.02.052
- Lu J, Lu Y, Wang X, et al. Prevalence, awareness, treatment,
and control of hypertension in China: data from 1·7 million adults
in a population-based screening study (China PEACE Million Persons
Project). The Lancet. 2017;390(10112):2549-2558.
doi:10.1016/S0140-6736(17)32478-9
- Wang Zengwu, Chen Zuo, Zhang Linfeng, et al. Status of
Hypertension in China. Circulation.
2018;137(22):2344-2356. doi:10.1161/CIRCULATIONAHA.117.032380
- Hu C, Jia W. Diabetes in China: Epidemiology and Genetic Risk
Factors and Their Clinical Utility in Personalized Medication.
Diabetes. 2018;67(1):3-11. doi:10.2337/dbi17-0013
- Yuan H, Li X, Wan G, et al. Type 2 diabetes epidemic in East
Asia: a 35-year systematic trend analysis. Oncotarget.
2018;9(6). doi:10.18632/oncotarget.22961
- Woo KS, Nicholls MG. High prevalence of persistent cough with
angiotensin converting enzyme inhibitors in Chinese. Br J Clin
Pharmacol. 1995;40(2):141-144.
- Chen X, Hu W, Ling J, et al. Hypertension and Diabetes Delay
the Viral Clearance in COVID-19 Patients. medRxiv. March
2020:2020.03.22.20040774. doi:10.1101/2020.03.22.20040774
- Perico L, Benigni A, Remuzzi G. Should COVID-19 Concern
Nephrologists? Why and to What Extent? The Emerging Impasse of
Angiotensin Blockade. NEF. March 2020:1-9.
doi:10.1159/000507305
- Qiao Y, Shin J-I, Chen TK, et al. Association Between
Renin-Angiotensin System Blockade Discontinuation and All-Cause
Mortality Among Persons With Low Estimated Glomerular Filtration
Rate. JAMA Intern Med. March 2020.
doi:10.1001/jamainternmed.2020.0193
- The Local. UPDATE - Coronavirus: French health minister and WHO
issue warning over taking anti-inflammatories.
https://www.thelocal.fr/20200314/coronavirus-french-health-minister-issues-warning-over-anti-flammatories.
Published March 14, 2020. Accessed March 30, 2020.
- ScienceAlert. Updated: WHO Now Doesn’t Recommend Avoiding
Ibuprofen For COVID-19 Symptoms.
https://www.sciencealert.com/who-recommends-to-avoid-taking-ibuprofen-for-covid-19-symptoms.
Accessed March 30, 2020.
- European Medicines Agency. Coronavirus disease (COVID-19).
https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19#advice-on-using-non-steroidal-anti-inflammatory-medicines-such-as-ibuprofen--section.
Published March 18, 2020.
- U.S. Food and Drug Administration. FDA advises patients on use
of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19.
https://www.fda.gov/drugs/drug-safety-and-availability/fda-advises-patients-use-non-steroidal-anti-inflammatory-drugs-nsaids-covid-19.
Published March 19, 2020.
- BBC Reality Check team and BBC Monitoring. Coronavirus and
ibuprofen: Separating fact from fiction. BBC News.
https://www.bbc.com/news/51929628. Published March 17, 2020.
- Mosbergen D. Tylenol Overdose Risk Is Staggering; Acetaminophen
Safeguards Remain Insufficient: Report. HuffPost.
https://www.huffpost.com/entry/tylenol-overdose_n_3976991.
Published September 24, 2013.