Aug 29, 2017
Author: Dylan Luyten, M.D.
- Hypoglycemia is very common in type 2
diabetics, and is often caused by insulin overdose or missed meals.
Knowing the peak time of action for common diabetes medications can
help inform treatment and disposition.
- Regular insulin’s action peaks around 60
minutes. By the time most of these patients present to the ED, the
drug has had most of its effect.
- Lantis’ action does not peak, and will continue
to exert its effect for 12 or more hours.
- Levamir has a peak around 6-8
- Metformin sensitizes tissues to insulin, so it
cannot cause hypoglycemia alone.
- Glipizides have half-lives over 12 hours and
work by increasing insulin release by the pancreas. Hypoglycemia in
a patient taking a glipizide usually indicates there is another
medical issue interfering with clearance