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Emergency Medical Minute


Jan 25, 2021

Contributor: Dylan Luyten, MD

Educational Pearls:

  • D10 may be a better alternative to D50 in correcting hypoglycemia
  • Risks of D50: 
    • Can cause extravasation injury
    • Risk of rebound hypoglycemia
  • D10 does not have the same risks and has no significant difference in reversal time of hypoglycemia compared to D50


Kiefer MV, Gene Hern H, Alter HJ, Barger JB. Dextrose 10% in the treatment of out-of-hospital hypoglycemia. Prehosp Disaster Med. 2014 Apr;29(2):190-4. doi: 10.1017/S1049023X14000284. Epub 2014 Apr 15. PMID: 24735872.

Moore C, Woollard M. Dextrose 10% or 50% in the treatment of hypoglycaemia out of hospital? A randomised controlled trial. Emerg Med J. 2005 Jul;22(7):512-5. doi: 10.1136/emj.2004.020693. PMID: 15983093; PMCID: PMC1726850.

Summarized by John Spartz, MS3 | Edited by Erik Verzemnieks, MD

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